CERS6 and OPRL1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CERS6	OPRL1
Description		ceramide synthase 6	opioid related nociceptin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Neuron Projection
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity	Nociceptin Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein C-terminus Binding Peptide Binding Neuropeptide Binding
	Biological Process	Inflammatory Response Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Sensory Perception Of Pain Response To Estradiol Positive Regulation Of Urine Volume G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Negative Regulation Of CAMP-mediated Signaling Estrous Cycle Negative Regulation Of Blood Pressure Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Gastric Acid Secretion Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Conditioned Place Preference
Pathways		Sphingolipid de novo biosynthesis	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Bipolar disorder ( 31043756) Parkinson's disease ( 27182965) Recurrent major depressive disorder ( 34099189) Recurrent major depressive disorder x sex interaction ( 34099189) Red cell distribution width ( 32888494 27863252 28957414) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)	Body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: AGTR1 OPRL1 SEC22B	10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2
Entrez ID		253782	4987
HPRD ID		17258	03971
Ensembl ID		ENSG00000172292	ENSG00000125510
Uniprot IDs		Q6ZMG9	A0A5F9ZI64 P41146 Q8IXB0
PDB IDs			4EA3 5DHG 5DHH
Enriched GO Terms of Interacting Partners?
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