MX1 and TRPC4

Number of citations of the paper that reports this interaction (PubMedID 15757897)
12

Data Source:
HPRD (in vitro, in vivo)

		MX1	TRPC4
Description		MX dynamin like GTPase 1	transient receptor potential cation channel subfamily C member 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Microtubule Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Cation Channel Complex Calcium Channel Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding	Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Apoptotic Process Defense Response Signal Transduction Response To Virus Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response	Calcium Ion Transport Manganese Ion Transport Gamma-aminobutyric Acid Secretion Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		55 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CCL16 CD5 CHD3 DAXX DCP2 EPM2AIP1 FANCA FXR1 GGPS1 GMEB1 GPC4 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 MX2 NDC80 NDUFV3 PDE9A PGRMC1 PIAS1 PIAS2 PLRG1 PRDX6 PSD3 PSG9 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZFP36 ZNF251 ZNF623	10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5
Entrez ID		4599	7223
HPRD ID		00919	09154
Ensembl ID		ENSG00000157601	ENSG00000133107
Uniprot IDs		P20591	Q9UBN4
PDB IDs		3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?
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