MSH5 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 32814904)
20

Data Source:
BioGRID (pull down)

		MSH5	MLH3
Description		mutS homolog 5	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Mismatched DNA Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Meiotic Mismatch Repair Reciprocal Meiotic Recombination	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 28240269) Body shape index ( 34021172) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lung cancer ( 18978787) Mastocytosis ( 32752121) Medication use (anilides) ( 31015401) Menopause (age at onset) ( 26414677) Pulse pressure ( 27618448) Systemic lupus erythematosus ( 26316170) Systemic mastocytosis ( 32752121) Systolic blood pressure ( 27618448) Takayasu arteritis ( 25604533) Ulcerative colitis ( 24837172 28067908)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: MLH1 MLH3 MSH4 NEU1 NOTCH4 TRIM54	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		4439	27030
HPRD ID		04544	05094
Ensembl ID		ENSG00000204410	ENSG00000119684
Uniprot IDs		A0A024RCM1 A0A024RCV6 O43196	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?
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