MLH3 and CTSV

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		MLH3	CTSV
Description		mutL homolog 3	cathepsin V
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Extracellular Region Extracellular Space Lysosome Microvillus External Side Of Plasma Membrane Secretory Granule Neuron Projection Lysosomal Lumen Perikaryon Apical Part Of Cell
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding	Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Kininogen Binding Peptide Binding Protein-containing Complex Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization	Immune Response Spermatogenesis Cellular Response To Starvation Response To Glucose Multicellular Organism Aging Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Nerve Development Extracellular Matrix Disassembly Response To Gonadotropin Decidualization Autophagic Cell Death Response To Glucocorticoid Proteolysis Involved In Cellular Protein Catabolic Process Sertoli Cell Differentiation Response To Odorant
Pathways		Meiotic recombination	Endosomal/Vacuolar pathway Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs			3-amino-5-phenylpentane 4-Methylpiperazin-1-Yl Carbonyl Group
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	14 interacting genes: APC BMPR1A BRAF BUB1 CDKN2A CTNNA1 DCC DLC1 KCNJ1 MLH1 MLH3 PDGFRL RB1 SRC
Entrez ID		27030	1515
HPRD ID		05094	04495
Ensembl ID		ENSG00000119684	ENSG00000136943
Uniprot IDs		Q2M1Z1 Q9UHC1	A0A024R141 B2R717 O60911
PDB IDs			1FH0 3H6S 3KFQ
Enriched GO Terms of Interacting Partners?
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