MLH3 and HSD17B3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		MLH3	HSD17B3
Description		mutL homolog 3	hydroxysteroid 17-beta dehydrogenase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding	Oxidoreductase Activity Testosterone Dehydrogenase [NAD(P)] Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization	Steroid Biosynthetic Process Androgen Biosynthetic Process Male Genitalia Development Testosterone Biosynthetic Process
Pathways		Meiotic recombination	Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs			NADH
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Cerebrospinal fluid AB1-42 levels ( 26252872) Glomerular filtration rate in chronic kidney disease ( 26420894) Letter-number span reordering ( 31596458)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	9 interacting genes: BRAF BUB1 CDH1 CTNNA1 DLC1 ERBB2 MCC MLH3 SMAD2
Entrez ID		27030	3293
HPRD ID		05094	05716
Ensembl ID		ENSG00000119684	ENSG00000130948
Uniprot IDs		Q2M1Z1 Q9UHC1	P37058 Q6FH62
PDB IDs
Enriched GO Terms of Interacting Partners?
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