MSH5 and MSH4

Number of citations of the paper that reports this interaction (PubMedID 10029069)
30

Data Source:
HPRD (two hybrid, in vitro)

		MSH5	MSH4
Description		mutS homolog 5	mutS homolog 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome	Synaptonemal Complex Nucleus Chromosome Recombination Nodule
	Molecular Function	Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Mismatched DNA Binding	DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Mismatched DNA Binding
	Biological Process	Meiotic Mismatch Repair Reciprocal Meiotic Recombination	Meiotic Mismatch Repair Resolution Of Meiotic Recombination Intermediates Ovarian Follicle Development Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 28240269) Body shape index ( 34021172) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lung cancer ( 18978787) Mastocytosis ( 32752121) Medication use (anilides) ( 31015401) Menopause (age at onset) ( 26414677) Pulse pressure ( 27618448) Systemic lupus erythematosus ( 26316170) Systemic mastocytosis ( 32752121) Systolic blood pressure ( 27618448) Takayasu arteritis ( 25604533) Ulcerative colitis ( 24837172 28067908)	Attention function in attention deficit hyperactive disorder ( 26174813) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Serum metabolite levels ( 23093944)
Interacting Genes		6 interacting genes: MLH1 MLH3 MSH4 NEU1 NOTCH4 TRIM54	9 interacting genes: ACADM DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1
Entrez ID		4439	4438
HPRD ID		04544	03658
Ensembl ID		ENSG00000204410	ENSG00000057468
Uniprot IDs		A0A024RCM1 A0A024RCV6 O43196	O15457
PDB IDs
Enriched GO Terms of Interacting Partners?
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