MAP3K1 and MAP2K7

  • Number of citations of the paper that reports this interaction (PubMedID 15866172)
  • 49

MAP3K1

MAP2K7

Description mitogen-activated protein kinase kinase kinase 1 mitogen-activated protein kinase kinase 7
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alanine aminotransferase levels ( 33547301 33339817)
  • Alanine transaminase levels ( 29403010)
  • Blond vs. brown/black hair color ( 30531825)
  • Body shape index ( 34021172)
  • Brain morphology (MOSTest) ( 32665545)
  • Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030)
  • Breast cancer (early onset) ( 24493630)
  • Brown vs. black hair color ( 30531825)
  • Coronary artery disease ( 29212778)
  • Cortical surface area (MOSTest) ( 32665545)
  • Fasting blood insulin ( 25631608)
  • Fasting glucose in pregnancy (gestational week 14-16) ( 30324795)
  • Fasting insulin ( 33402679)
  • Fasting insulin (dietary factor interaction) ( 24204828)
  • Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828)
  • Initial pursuit acceleration ( 29064472)
  • Lung function (FEV1) ( 30061609)
  • Refractive error ( 32231278)
  • Serum alkaline phosphatase levels ( 33547301)
  • Sexual dimorphism in anthropometric traits ( 23754948)
  • Subcortical volume (MOSTest) ( 32665545)
  • Triglyceride levels ( 28334899 32902719)
  • Triglycerides ( 24097068 20686565)
  • Type 2 diabetes ( 23209189)
  • Urate levels (BMI interaction) ( 25811787)
  • Waist circumference ( 23966867)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412 28448500)
  • Waist-hip index ( 34021172)
  • Waist-hip ratio ( 25673412)
  • Waist-to-hip ratio adjusted for BMI ( 34021172 26426971)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
  • Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
  • Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
  • Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
  • White matter hyperintensity volume ( 33293549)
  • White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
  • White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
  • Youthful appearance (self-reported) ( 32339537)
Interacting Genes 97 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHRM5 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RIPK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1 TOM1L2 TP53 TRAF2 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 YWHAE ZFAND3 ZFAND5 33 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B ICAM1 JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2
Entrez ID 4214 5609
HPRD ID 19599 04309
Ensembl ID ENSG00000095015 ENSG00000076984
Uniprot IDs Q13233 B4DV95 O14733
PDB IDs 6WHB 2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX
Enriched GO Terms of Interacting Partners?
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