MAP2K7 and MAP3K13

Number of citations of the paper that reports this interaction (PubMedID 11726277)
12

Data Source:
BioGRID (enzymatic study)

		MAP2K7	MAP3K13
Description		mitogen-activated protein kinase kinase 7	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Membrane
	Molecular Function	Magnesium Ion Binding MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein Serine Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding IkappaB Kinase Complex Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Telomerase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Senescence Positive Regulation Of Telomere Capping	Protein Phosphorylation JNK Cascade Positive Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs			Fostamatinib
Diseases
GWAS		Fasting insulin ( 34059833) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)	Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822) Neonatal white matter microstructure ( 33009551)
Interacting Genes		33 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B ICAM1 JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2	9 interacting genes: CD44 GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		5609	9175
HPRD ID		04309	05372
Ensembl ID		ENSG00000076984	ENSG00000073803
Uniprot IDs		B4DV95 O14733	O43283
PDB IDs		2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX
Enriched GO Terms of Interacting Partners?
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