MAP3K1 and UBQLN1

  • Number of citations of the paper that reports this interaction (PubMedID 25260751)
  • 14
  • Data Source:
  • BioGRID (enzymatic study)

MAP3K1

UBQLN1

Description mitogen-activated protein kinase kinase kinase 1 ubiquilin 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alanine aminotransferase levels ( 33547301 33339817)
  • Alanine transaminase levels ( 29403010)
  • Blond vs. brown/black hair color ( 30531825)
  • Body shape index ( 34021172)
  • Brain morphology (MOSTest) ( 32665545)
  • Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030)
  • Breast cancer (early onset) ( 24493630)
  • Brown vs. black hair color ( 30531825)
  • Coronary artery disease ( 29212778)
  • Cortical surface area (MOSTest) ( 32665545)
  • Fasting blood insulin ( 25631608)
  • Fasting glucose in pregnancy (gestational week 14-16) ( 30324795)
  • Fasting insulin ( 33402679)
  • Fasting insulin (dietary factor interaction) ( 24204828)
  • Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828)
  • Initial pursuit acceleration ( 29064472)
  • Lung function (FEV1) ( 30061609)
  • Refractive error ( 32231278)
  • Serum alkaline phosphatase levels ( 33547301)
  • Sexual dimorphism in anthropometric traits ( 23754948)
  • Subcortical volume (MOSTest) ( 32665545)
  • Triglyceride levels ( 28334899 32902719)
  • Triglycerides ( 24097068 20686565)
  • Type 2 diabetes ( 23209189)
  • Urate levels (BMI interaction) ( 25811787)
  • Waist circumference ( 23966867)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412 28448500)
  • Waist-hip index ( 34021172)
  • Waist-hip ratio ( 25673412)
  • Waist-to-hip ratio adjusted for BMI ( 34021172 26426971)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
  • Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
  • Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
  • Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
  • White matter hyperintensity volume ( 33293549)
  • White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
  • White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
  • Youthful appearance (self-reported) ( 32339537)
Interacting Genes 97 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHRM5 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RIPK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1 TOM1L2 TP53 TRAF2 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 YWHAE ZFAND3 ZFAND5 233 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 ANOS1 APOC2 APOC4 APP ASCL1 ATXN3 BAG6 BPIFA1 C1QA C1QTNF2 C1QTNF4 CALU CCL3 CCL7 CD47 CD99 CD99L2 CDIP1 CDSN CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COL9A2 COLGALT2 COMTD1 COPS4 CSN3 CSTF2 CSTF2T CTAG1A CTAG1B CTAG2 CYB5R1 DAZAP2 DEFA6 DEFB115 DESI1 DEXI DMKN DNAJB2 DOLK ECM1 EFEMP2 EP300 EPS15 ERP27 ERP29 ETNK1 F8 FAM163B FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FOLR3 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GAL GHRL GIT2 GKAP1 GPR162 GPX3 GRM2 GUCA2A GUCA2B GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IER3IP1 IGFBP6 IGL IGLC1 IGLV2-14 IL6ST IRF1-AS1 IST1 ITPRIPL1 JPH4 JSRP1 KLHL42 LAIR2 LAMB1 LCN2 LHX4 LITAF LNPEP MANBAL MAP3K1 MCM7 MDK MESD MICOS10-NBL1 MIEF1 MIEF2 MLLT6 MTNR1A MTOR MYDGF NAXD NBL1 NDE1 NDOR1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 NXF1 OST4 P4HB PARVA PBXIP1 PCDH18 PCDHA4 PIAS2 PIK3IP1 PLAAT1 PLAAT2 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PRR4 PSEN1 PSEN2 PSMD4 PSMD6 PSORS1C2 PTN RAI2 RARA RASSF5 RIC8A RNF144B RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SEZ6L SIL1 SLC16A3 SLC29A2 SLPI SMAD9 SMIM19 SMIM2 SMR3B SMURF1 SOD3 SPAG8 SPARC SRGN STAM2 STMN3 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM258 TMEM31 TMEM37 TMEM67 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM23 TRIM32 TXNDC12 UBA52 UBB UBC UBE2I UBE2V1 UBE3A UBQLN2 UBQLN4 UBXN1 UBXN4 UBXN7 VWC2 WBP2 WFDC12 XPO4 ZBTB8B ZFAND2B ZG16 ZG16B ZMYM5 ZNF343
Entrez ID 4214 29979
HPRD ID 19599 05440
Ensembl ID ENSG00000095015 ENSG00000135018
Uniprot IDs Q13233 A0A024R258 Q9UMX0
PDB IDs 6WHB 2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?
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