MAP3K1 and MAPK1

  • Number of citations of the paper that reports this interaction (PubMedID 10969079)
  • 31
  • Data Source:
  • BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study)
  • HPRD (in vivo)

MAP3K1

MAPK1

Description mitogen-activated protein kinase kinase kinase 1 mitogen-activated protein kinase 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alanine aminotransferase levels ( 33547301 33339817)
  • Alanine transaminase levels ( 29403010)
  • Blond vs. brown/black hair color ( 30531825)
  • Body shape index ( 34021172)
  • Brain morphology (MOSTest) ( 32665545)
  • Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030)
  • Breast cancer (early onset) ( 24493630)
  • Brown vs. black hair color ( 30531825)
  • Coronary artery disease ( 29212778)
  • Cortical surface area (MOSTest) ( 32665545)
  • Fasting blood insulin ( 25631608)
  • Fasting glucose in pregnancy (gestational week 14-16) ( 30324795)
  • Fasting insulin ( 33402679)
  • Fasting insulin (dietary factor interaction) ( 24204828)
  • Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828)
  • Initial pursuit acceleration ( 29064472)
  • Lung function (FEV1) ( 30061609)
  • Refractive error ( 32231278)
  • Serum alkaline phosphatase levels ( 33547301)
  • Sexual dimorphism in anthropometric traits ( 23754948)
  • Subcortical volume (MOSTest) ( 32665545)
  • Triglyceride levels ( 28334899 32902719)
  • Triglycerides ( 24097068 20686565)
  • Type 2 diabetes ( 23209189)
  • Urate levels (BMI interaction) ( 25811787)
  • Waist circumference ( 23966867)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412 28448500)
  • Waist-hip index ( 34021172)
  • Waist-hip ratio ( 25673412)
  • Waist-to-hip ratio adjusted for BMI ( 34021172 26426971)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
  • Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
  • Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
  • Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
  • White matter hyperintensity volume ( 33293549)
  • White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
  • White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
  • Youthful appearance (self-reported) ( 32339537)
Interacting Genes 97 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHRM5 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RIPK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1 TOM1L2 TP53 TRAF2 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 YWHAE ZFAND3 ZFAND5 251 interacting genes: AR ARRB1 ARRB2 ATF2 ATP1A1 BANP BCL2 BCL3 BCL6 BRAF C1QBP CACYBP CAD CALCOCO1 CAPN2 CASP8 CASP9 CAV1 CD19 CDC25C CDX2 CEBPB CEP55 CHN1 CITED2 CMTM3 COPS6 CREBBP CRP CSNK2A1 CTNND1 CTSD CUEDC2 DAPK1 DUSP1 DUSP16 DUSP2 DUSP3 DUSP4 DUSP5 DUSP6 DUSP7 DUSP9 DYRK1B EGFR EGLN3 EIF4EBP1 ELK1 ELK4 ENAH EP300 EPOR ERF ESR1 ESR2 ETS1 FCGR2B FHL3 FOS FOXO3 FRS2 FRS3 GAB1 GAB2 GABRR1 GAPDH GATA1 GATA2 GATA4 GJA1 GMFB GNPTAB GORASP2 GRB10 GRB2 GSK3B HDAC4 HDAC6 HIF1A HNF4A HOMEZ HSF1 HSF4 HSP90AA1 ID2 IER3 IFI35 IFNAR1 ILF3 IQGAP1 IRS1 ITGB6 JUN JUND KARS1 KDR KHDRBS1 KLF11 KRT8 KSR1 KSR2 LAMTOR3 LCK LIFR LIPE LRPAP1 LRRC4 LZTS2 MAFA MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAPK14 MAPK8 MAPKAPK5 MAPT MBP MCL1 MDFI METAP2 METTL3 MITF MKNK1 MKNK2 MSX2 MTIF3 MTPN MYB MYC NCOA1 NCOA3 NDE1 NEFH NEK2 NGFR NKX2-1 NOXA1 NR3C1 NR4A1 NR4A2 NR5A1 NRL NTRK3 NUP153 PAK1 PAK2 PAX5 PDE4D PEA15 PEBP1 PKM PLA2G4A PLAGL2 PLAT PLCB1 PLK3 POLR2G PPARA PPARG PPP1CA PPP1R18 PPP1R9B PPP2CA PPP2R5B PPP2R5C PRDX6 PRKCD PRKCE PRKCZ PRPSAP1 PSMA1 PTPDC1 PTPN1 PTPN5 PTPN7 PTPRC PTPRE PTPRH PTPRR PXN RAF1 RB1 REST RET RGS19 RNF216 RNF8 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RUNX1 RXRA SCNN1G SH2D3C SHANK3 SHC1 SLC9A1 SMAD1 SMAD2 SMAD3 SMAD4 SNCA SNCG SORBS3 SOS1 SOX10 SP1 SREBF1 SREBF2 STAT3 STAT5A STAT5B STXBP1 STYX SUPT20H TCF3 TFCP2 TGIF1 TH TIAL1 TLE5 TNFRSF1A TNFRSF25 TNFSF11 TNIP1 TNIP2 TNKS2 TOB1 TOP2A TP53 TPR TSC2 TTN TXNIP UBE3A UBR5 UBTF VAV1 VDR YBX1 YBX3 ZBTB42 ZC3HC1 ZFP36
Entrez ID 4214 5594
HPRD ID 19599 01496
Ensembl ID ENSG00000095015 ENSG00000100030
Uniprot IDs Q13233 P28482 Q1HBJ4 Q499G7
PDB IDs 6WHB 1PME 1TVO 1WZY 2OJG 2OJI 2OJJ 2Y9Q 3D42 3D44 3I5Z 3I60 3SA0 3TEI 3W55 4FMQ 4FUX 4FUY 4FV0 4FV1 4FV2 4FV3 4FV4 4FV5 4FV6 4FV7 4FV8 4FV9 4G6N 4G6O 4H3P 4H3Q 4IZ5 4IZ7 4IZA 4N0S 4NIF 4O6E 4QP1 4QP2 4QP3 4QP4 4QP6 4QP7 4QP8 4QP9 4QPA 4QTA 4QTE 4XJ0 4ZXT 4ZZM 4ZZN 4ZZO 5AX3 5BUE 5BUI 5BUJ 5BVD 5BVE 5BVF 5K4I 5LCJ 5LCK 5NGU 5NHF 5NHH 5NHJ 5NHL 5NHO 5NHP 5NHV 5V60 5V61 5V62 5WP1 6D5Y 6DMG 6G54 6G8X 6G91 6G92 6G93 6G97 6G9A 6G9D 6G9H 6G9J 6G9K 6G9M 6G9N 6GDM 6GDQ 6GE0 6GJB 6GJD 6NBS 6OPG 6OPH 6OPI 6Q7K 6Q7S 6Q7T 6QA1 6QA3 6QA4 6QAG 6QAH 6QAL 6QAQ 6QAW 6RQ4 6SLG
Enriched GO Terms of Interacting Partners?
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