SMAD6 and PIK3R4

		SMAD6	PIK3R4
Description		SMAD family member 6	phosphoinositide-3-kinase regulatory subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Protein-containing Complex Heteromeric SMAD Protein Complex	Late Endosome Autophagosome Cytosol Axoneme Microtubule Cytoskeleton Membrane Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Intracellular Membrane-bounded Organelle Nucleus-vacuole Junction
	Molecular Function	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding Transcription Regulator Inhibitor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Negative Regulation Of SMAD Protein Complex Assembly Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Protein Phosphorylation Protein Targeting To Vacuole Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Glucose Starvation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Late Endosome To Vacuole Transport
Pathways		Signaling by BMP RUNX2 regulates bone development	PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Asthma ( 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lung cancer (smoking interaction) ( 24658283) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Abdominal aortic calcification levels ( 31659325) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ANXA2 BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 MYO1E PIGB PIK3R4 PPIB RAB11A RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1 UACA	8 interacting genes: FNDC3B MAPRE1 NPHP3 NRBF2 PIK3C3 RACK1 SMAD6 YWHAB
Entrez ID		4091	30849
HPRD ID		04240	04010
Ensembl ID		ENSG00000137834	ENSG00000196455
Uniprot IDs		O43541	Q99570
PDB IDs			7BL1
Enriched GO Terms of Interacting Partners?
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