PIK3R4 and PIK3C3

Number of citations of the paper that reports this interaction (PubMedID 8999962)
64

Data Source:
HPRD (in vivo, in vitro)

		PIK3R4	PIK3C3
Description		phosphoinositide-3-kinase regulatory subunit 4	phosphatidylinositol 3-kinase catalytic subunit type 3
Image
GO Annotations	Cellular Component	Late Endosome Autophagosome Cytosol Axoneme Microtubule Cytoskeleton Membrane Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Intracellular Membrane-bounded Organelle Nucleus-vacuole Junction	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Peroxisome Cytosol Axoneme Membrane Midbody Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol Kinase Activity
	Biological Process	Protein Phosphorylation Protein Targeting To Vacuole Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Glucose Starvation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Late Endosome To Vacuole Transport	Autophagosome Assembly Protein Phosphorylation Protein Lipidation Endocytosis Autophagy Endosome Organization Cell Cycle Macroautophagy Protein Processing Autophagy Of Peroxisome Regulation Of Cytokinesis Protein Localization To Phagophore Assembly Site Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Response To Leucine Early Endosome To Late Endosome Transport Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Regulation Of Protein Secretion Cell Division
Pathways		PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs			N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Refractive error ( 32231278)	Adult body size ( 32376654) Blood trace element (Zn levels) ( 23720494) Body size at age 10 ( 32376654) Frailty index ( 34431594) General risk tolerance (MTAG) ( 30643258) Major depressive disorder (MTAG) ( 33479212) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966) Walking pace ( 33128006)
Interacting Genes		8 interacting genes: FNDC3B MAPRE1 NPHP3 NRBF2 PIK3C3 RACK1 SMAD6 YWHAB	10 interacting genes: CALM1 CASP8 FBXL20 OTUD7B PDPK1 PIK3R4 PITPNA STYK1 YWHAG YWHAQ
Entrez ID		30849	5289
HPRD ID		04010	04009
Ensembl ID		ENSG00000196455	ENSG00000078142
Uniprot IDs		Q99570	A8MYT4 B4DPV9 Q8NEB9
PDB IDs		7BL1	3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6I3U 7BL1
Enriched GO Terms of Interacting Partners?
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