PIK3R4 and NRBF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PIK3R4	NRBF2
Description		phosphoinositide-3-kinase regulatory subunit 4	nuclear receptor binding factor 2
Image
GO Annotations	Cellular Component	Late Endosome Autophagosome Cytosol Axoneme Microtubule Cytoskeleton Membrane Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Intracellular Membrane-bounded Organelle Nucleus-vacuole Junction	Nucleoplasm Cytoplasm Autophagosome Cytoplasmic Vesicle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Protein Targeting To Vacuole Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Glucose Starvation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Late Endosome To Vacuole Transport	Autophagy Response To Endoplasmic Reticulum Stress Regulation Of Lipid Kinase Activity
Pathways		PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Refractive error ( 32231278)	Atrial fibrillation ( 30061737) Fasting glucose ( 34059833) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Macular telangiectasia type 2 ( 33654266) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 24026423) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell count ( 32888494) Schizophrenia ( 28991256 30285260) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		8 interacting genes: FNDC3B MAPRE1 NPHP3 NRBF2 PIK3C3 RACK1 SMAD6 YWHAB	17 interacting genes: ARID5B C1orf216 CCNC CDC23 HNF4A IKBKG KDM1A PIK3R4 PPARA PRKAA2 RARA RHOU RPTOR RXRA SHANK3 THRB TSC1
Entrez ID		30849	29982
HPRD ID		04010	11401
Ensembl ID		ENSG00000196455	ENSG00000148572
Uniprot IDs		Q99570	Q96F24
PDB IDs		7BL1	4ZEY
Enriched GO Terms of Interacting Partners?
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