MAD2L1 and MAD1L1

Number of citations of the paper that reports this interaction (PubMedID 11459826)
52

Data Source:
HPRD (in vitro)

		MAD2L1	MAD1L1
Description		mitotic arrest deficient 2 like 1	mitotic arrest deficient 1 like 1
Image
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle	Kinetochore Nuclear Envelope Centrosome Spindle Cytosol Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Protein Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Identical Protein Binding Kinetochore Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin Protein Ligase Activity	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Coronary artery disease ( 32469254 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369) Myocardial infarction ( 33532862) Refractive error ( 32231278)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first birth ( 34211149) Age at first sexual intercourse ( 27089180 34211149) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety ( 31906708) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 28115744 21926972 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 33020668) Dimensional psychopathology (Social) ( 29496196) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Gastroesophageal reflux disease ( 34187846 31527586) General factor of neuroticism ( 30867560) Gut microbiota relative abundance (Streptococcus) ( 33208821) Hand grip strength ( 29691431) Idiopathic pulmonary fibrosis ( 31710517) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 28991256 29483656 22688191 30285260 23974872) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sepsis (28-day mortality) ( 32592749) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604728 28604732 23666239) Vaginal microbiome composition (Shannon diversity index) ( 32723796)
Interacting Genes		27 interacting genes: ADAM17 ANAPC2 ANAPC4 APP BBS7 CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD	79 interacting genes: AIMP2 ALOX5 AMOTL2 ANXA5 ATG5 BAG5 BIRC2 CAPN7 CCDC57 CCHCR1 CCND2 CDC37 CDK18 CHERP CHST12 COIL CWF19L2 FAM131C FAM90A1 FSCN1 FXR1 GAS8 GPKOW HAUS1 HDAC1 HDAC2 HOXA10 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 NXPH1 PIBF1 PIN4 PML PPP1R18 PRKAR1B PSMA1 RNF8 RPA3 S100P SIN3A SIN3B SPATA18 SPATA2 STAM SUPT5H SYT17 SYT6 TCAF1 TEX11 TEX33 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TTYH3 TUBGCP4 TULP4 UBC UBTF USP15 YJU2 ZSCAN32
Entrez ID		4085	8379
HPRD ID		03274	04065
Ensembl ID		ENSG00000164109	ENSG00000002822
Uniprot IDs		Q13257	Q9Y6D9
PDB IDs		1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ	1GO4 4DZO
Enriched GO Terms of Interacting Partners?
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