MAD2L1 and REV3L

Number of citations of the paper that reports this interaction (PubMedID 10660610)
76

Data Source:
BioGRID (pull down)

		MAD2L1	REV3L
Description		mitotic arrest deficient 2 like 1	REV3 like, DNA directed polymerase zeta catalytic subunit
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GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Zeta DNA Polymerase Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity	Nucleotide Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin Protein Ligase Activity	Double-strand Break Repair Via Homologous Recombination DNA-dependent DNA Replication Error-prone Translesion Synthesis
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		Coronary artery disease ( 32469254 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369) Myocardial infarction ( 33532862) Refractive error ( 32231278)	HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 28067908 23128233) Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 26414677) Psoriasis ( 25574825) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)
Interacting Genes		27 interacting genes: ADAM17 ANAPC2 ANAPC4 APP BBS7 CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD	6 interacting genes: CHEK2 HDAC2 HDAC4 MAD2L1 MAD2L2 REV1
Entrez ID		4085	5980
HPRD ID		03274	04145
Ensembl ID		ENSG00000164109	ENSG00000009413
Uniprot IDs		Q13257	O60673 Q9UG47
PDB IDs		1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5O8K 6BC8 6BCD 6BI7 6EKM 6KEA 6WS0 6WS5
Enriched GO Terms of Interacting Partners?
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