LIG1 and MIER1

Number of citations of the paper that reports this interaction (PubMedID 33097091)
0

Data Source:
BioGRID (unspecified method)

		LIG1	MIER1
Description		DNA ligase 1	MIER1 transcriptional regulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-containing Complex
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding	Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Histone Deacetylase Binding
	Biological Process	DNA Ligation Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Mismatch Repair Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand
Drugs		Bleomycin
Diseases
GWAS			Allergic rhinitis ( 30013184) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		19 interacting genes: CBX3 CDY1 CDYL CDYL2 CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 L3MBTL3 MIER1 MRE11 PCNA PHF20 PRKCB RGS2 TUBB3 UHRF1	7 interacting genes: APP CREBBP H3-4 HDAC1 LIG1 SP1 TMEM171
Entrez ID		3978	57708
HPRD ID		00534	11362
Ensembl ID		ENSG00000105486	ENSG00000198160
Uniprot IDs		B4DM52 F5GZ28 P18858	Q8N108
PDB IDs		1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V 7KR3 7KR4 7L34 7L35
Enriched GO Terms of Interacting Partners?
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