ARHGAP6 and TEC

		ARHGAP6	TEC
Description		Rho GTPase activating protein 6	tec protein tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Actin Cytoskeleton	Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	GTPase Activator Activity Phospholipase Activator Activity SH3 Domain Binding Phospholipase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Activation Of Phospholipase C Activity Rho Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of GTPase Activity Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		RHOA GTPase cycle RAC3 GTPase cycle	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)
Interacting Genes		2 interacting genes: LNX1 TEC	42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS
Entrez ID		395	7006
HPRD ID		02124	02786
Ensembl ID		ENSG00000047648	ENSG00000135605
Uniprot IDs		O43182 Q59HG6	P42680
PDB IDs			2LUL
Enriched GO Terms of Interacting Partners?
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