TEC and PIP5K1A

Number of citations of the paper that reports this interaction (PubMedID 14614854)
62

Data Source:
HPRD (in vivo, in vitro)

		TEC	PIP5K1A
Description		tec protein tyrosine kinase	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Nucleus Nucleoplasm Cytosol Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding	1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding 1-phosphatidylinositol-5-kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
	Biological Process	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Regulation Of Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Phosphatidylinositol Phosphate Biosynthetic Process Focal Adhesion Assembly Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)	Body mass index ( 26426971)
Interacting Genes		42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS	16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC
Entrez ID		7006	8394
HPRD ID		02786	04470
Ensembl ID		ENSG00000135605	ENSG00000143398
Uniprot IDs		P42680	A6PW57 Q99755
PDB IDs		2LUL
Enriched GO Terms of Interacting Partners?
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