TEC and PTPN18

Number of citations of the paper that reports this interaction (PubMedID 15588985)
74

Data Source:
HPRD (in vitro)

		TEC	PTPN18
Description		tec protein tyrosine kinase	protein tyrosine phosphatase non-receptor type 18
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Blastocyst Formation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of ERBB Signaling Pathway
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	Downregulation of ERBB2 signaling Interleukin-37 signaling
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)
Interacting Genes		42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS	12 interacting genes: AATK ABL1 ARHGAP5 CDK2 CSK EGFR ERBB2 GAB1 PSTPIP1 PSTPIP2 SRC TEC
Entrez ID		7006	26469
HPRD ID		02786	05961
Ensembl ID		ENSG00000135605	ENSG00000072135
Uniprot IDs		P42680	Q99952
PDB IDs		2LUL	2OC3 4GFU 4GFV 4NND
Enriched GO Terms of Interacting Partners?
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