TEC and VAV1

Number of citations of the paper that reports this interaction (PubMedID 7651724)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		TEC	VAV1
Description		tec protein tyrosine kinase	vav guanine nucleotide exchange factor 1
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Metal Ion Binding Phosphorylation-dependent Protein Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Immune Response G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Platelet Activation T Cell Differentiation Neutrophil Chemotaxis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)	Blood protein levels ( 30072576) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494 27863252) Periodontitis ( 23459936) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS	82 interacting genes: ABL1 ACTA1 AOC3 AR ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 ERBB4 EZH2 FGFR1 FYN GAB1 GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 PTPRC RAC1 RACGAP1 RAF1 RHOA RHOG RIMS1 S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SMARCA4 SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX
Entrez ID		7006	7409
HPRD ID		02786	01284
Ensembl ID		ENSG00000135605	ENSG00000141968
Uniprot IDs		P42680	A0A0A0MR07 B2R8B5 P15498 Q96D37
PDB IDs		2LUL	2CRH 2LCT 2MC1 2ROR 3BJI 3KY9 6NEW 6NF1 6NFA
Enriched GO Terms of Interacting Partners?
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