HGFAC and SLC30A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HGFAC	SLC30A2
Description		HGF activator	solute carrier family 30 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Cytosol	Cytoplasm Lysosomal Membrane Late Endosome Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Zinc Ion Transmembrane Transporter Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Blood Coagulation Zymogen Activation	Response To Zinc Ion Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Sequestering Of Zinc Ion Zinc Ion Transmembrane Transport
Pathways		MET Receptor Activation	Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163 31015462) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gamma glutamyl transferase levels ( 29403010 33339817) Height ( 31562340 29782485) Hepatocyte growth factor levels ( 27989323 25998175) Inflammatory bowel disease ( 26192919) Iron status biomarkers (total iron binding capacity) ( 33536631) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 30578418) Serum total protein level ( 29403010) Triglyceride levels ( 32203549 32154731 29403010 33339817 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)
Interacting Genes		10 interacting genes: APPBP2 CCHCR1 F2 GOLM1 HGF KLKB1 SLC30A2 SPINT1 SPINT2 VSIG1	66 interacting genes: ABHD16A ADAM33 AQP2 AQP6 ATP13A1 C5orf46 CCL4 CCL4L2 CD40 CD52 CD79A CD99L2 CPLX4 CREB3 CTSA CYB561D2 EBAG9 EMP3 EVI2B F11R FAM174A FDPS FFAR2 FXYD3 FXYD6 GALNT15 GJA5 GJB2 GJB5 GLB1 GOLT1A GPR161 GPR42 GPRC5D HGFAC KASH5 KCNN4 LMNA LTA LYVE1 MS4A13 NDUFAF1 NRM OPRM1 PCNX2 PLPPR1 PVR SEC22A SELL SERPING1 SLC10A6 SLC16A2 SLC18A1 SLC38A7 SLC39A2 SLC7A1 SLC7A8 TAS2R5 TM4SF18 TMEM107 TMEM52B TMEM60 TMEM86A TNFRSF12A TRARG1 YIPF2
Entrez ID		3083	7780
HPRD ID		05184	18057
Ensembl ID		ENSG00000109758	ENSG00000158014
Uniprot IDs		D6RAR4 Q04756	Q9BRI3
PDB IDs		1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U
Enriched GO Terms of Interacting Partners?
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