BRMS1 and ANGPTL4

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		BRMS1	ANGPTL4
Description		BRMS1 transcriptional repressor and anoikis regulator	angiopoietin like 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Blood Microparticle
	Molecular Function	Protein Binding Histone Deacetylase Binding NF-kappaB Binding	Enzyme Inhibitor Activity Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis	Angiogenesis Response To Hypoxia Lipid Metabolic Process Negative Regulation Of Apoptotic Process Protein Unfolding Positive Regulation Of Angiogenesis Negative Regulation Of Lipoprotein Lipase Activity Triglyceride Homeostasis Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		HDACs deacetylate histones Potential therapeutics for SARS	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 28270201 24507774 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 33532862) Phospholipid levels in large HDL ( 29084231) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels in HDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels ( 32203549 32154731 33339817 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24507774 30275531 25961943 27036123) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		49 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SUDS3 TAF1 THRSP UBE2D1	9 interacting genes: AURKA BRMS1 CASP8 CDKN2A CDKN2C ESR1 FBXW7 FGFR4 TGFB1
Entrez ID		25855	51129
HPRD ID		05879	16173
Ensembl ID		ENSG00000174744	ENSG00000167772
Uniprot IDs		G5E9I4 Q9HCU9	Q9BY76
PDB IDs		2XUS 4AUV	6EUB 6U0A 6U1U 6U73
Enriched GO Terms of Interacting Partners?
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