RASGRP3 and HSD17B11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RASGRP3	HSD17B11
Description		RAS guanyl releasing protein 3	hydroxysteroid 17-beta dehydrogenase 11
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Kinase Binding Diacylglycerol Binding Small GTPase Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	MAPK Cascade Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity	Estrogen Biosynthetic Process Androgen Catabolic Process
Pathways		Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade	Estrogen biosynthesis
Drugs			Aetiocholanolone
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 33272962 26663301 28714469 19838193)	Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		12 interacting genes: APP DYNC2LI1 DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2	54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC22A18 SLC25A46 SLC30A8 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6
Entrez ID		25780	51170
HPRD ID		15213	10881
Ensembl ID		ENSG00000152689	ENSG00000198189
Uniprot IDs		Q8IV61	Q8NBQ5
PDB IDs			1YB1
Enriched GO Terms of Interacting Partners?
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