HSD17B11 and SLC22A18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSD17B11	SLC22A18
Description		hydroxysteroid 17-beta dehydrogenase 11	solute carrier family 22 member 18
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Nuclear Envelope Cytoplasm Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Protein Binding Symporter Activity Solute:proton Antiporter Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding
	Biological Process	Estrogen Biosynthetic Process Androgen Catabolic Process	Excretion Organic Cation Transport Xenobiotic Transport Proton Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Estrogen biosynthesis	Organic cation transport Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
Drugs		Aetiocholanolone
Diseases
GWAS		Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)	Apolipoprotein A1 levels ( 32203549) Bilirubin levels ( 19414484) Calcium levels ( 20705733) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) Malaria ( 31844061) Total bilirubin levels ( 29403010)
Interacting Genes		54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC22A18 SLC25A46 SLC30A8 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6	6 interacting genes: HSD17B11 NKX3-1 RNF167 RRM1 TLCD4 TMX2
Entrez ID		51170	5002
HPRD ID		10881	04024
Ensembl ID		ENSG00000198189	ENSG00000110628
Uniprot IDs		Q8NBQ5	E9PRM7 Q96BI1
PDB IDs		1YB1
Enriched GO Terms of Interacting Partners?
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