POLA2 and CRELD1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	CRELD1
Description		DNA polymerase alpha 2, accessory subunit	cysteine rich with EGF like domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Molecular_function DNA Binding Protein Binding	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation	Endocardial Cushion Development Cardiac Septum Development
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)	Blood protein levels ( 30072576 29875488)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	17 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HOXA1 HTR2C KAT5 MAP3K1 MTNR1B NUFIP2 POLA2 PTN SETDB1 SHANK3 ZNF408
Entrez ID		23649	78987
HPRD ID		10160	06206
Ensembl ID		ENSG00000014138	ENSG00000163703
Uniprot IDs		Q14181	A0A024R2G1 Q96HD1
PDB IDs		2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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