POLA2 and ATP5F1C

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	ATP5F1C
Description		DNA polymerase alpha 2, accessory subunit	ATP synthase F1 subunit gamma
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Sector F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix Membrane
	Molecular Function	Molecular_function DNA Binding Protein Binding	RNA Binding Protein Binding ATP Hydrolysis Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation	Oxidative Phosphorylation ATP Biosynthetic Process ATP Synthesis Coupled Proton Transport Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs		Dacarbazine	Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
Diseases
GWAS		Acne (severe) ( 24927181) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	30 interacting genes: APP ATP5F1A ATP5F1B CA12 CCND3 CCT7 CDC42 CHMP2B DPP3 DUX4 EGFR ELOF1 ERCC6 FBXO7 GATA3 GDPD2 ITIH2 MED15 MEOX2 MPP1 NDUFB3 NGEF PAWR PJA1 PNO1 POLA2 PTEN PTN SERPINA1 ZNF337
Entrez ID		23649	509
HPRD ID		10160	00156
Ensembl ID		ENSG00000014138	ENSG00000165629
Uniprot IDs		Q14181	B4DL14 P36542 Q8TAS0
PDB IDs		2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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