POLA2 and PRIM2

Number of citations of the paper that reports this interaction (PubMedID 22939629)
326

Data Source:
BioGRID (pull down, biochemical, biochemical)

		POLA2	PRIM2
Description		DNA polymerase alpha 2, accessory subunit	DNA primase subunit 2
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Nucleoplasm Alpha DNA Polymerase:primase Complex
	Molecular Function	Molecular_function DNA Binding Protein Binding	DNA Binding Protein Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding DNA/RNA Hybrid Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation	DNA Replication, Synthesis Of RNA Primer Positive Regulation Of DNA Primase Activity
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)	Chronotype ( 30696823) Coronary artery disease ( 33020668) Daytime nap ( 33568662) Myocardial infarction ( 33532862) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Systemic lupus erythematosus ( 28714469)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	9 interacting genes: GTF3C6 KDM1A OGT POLA1 POLA2 PRIM1 RECK RUNX2 SUV39H1
Entrez ID		23649	5558
HPRD ID		10160	08900
Ensembl ID		ENSG00000014138	ENSG00000146143
Uniprot IDs		Q14181	A0A024RD43 P49643
PDB IDs		2KEB 4E2I 4Y97 5EXR	3L9Q 3Q36 4BPU 4BPW 4BPX 4RR2 5DQO 5EXR 5F0Q 5F0S 5I7M 6DHW
Enriched GO Terms of Interacting Partners?
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