POLA2 and ZNRD2

		POLA2	ZNRD2
Description		DNA polymerase alpha 2, accessory subunit	zinc ribbon domain containing 2
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GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Molecular_function DNA Binding Protein Binding	Protein Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation	Mitotic Cell Cycle Cell Division
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)	Glaucoma (primary open-angle) ( 33627673)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	27 interacting genes: ACTN2 C2CD6 CCDC33 CCNH CCT2 CCT3 CCT5 CCT7 FNDC11 FXR2 IL16 INCA1 MYO15B NME6 NOC4L PIAS2 POLA2 RNF115 RNF4 SNAPC5 STAT3 SUMO1P1 TRAF3IP3 TRAPPC6A UBE2I VTA1 ZMYM5
Entrez ID		23649	10534
HPRD ID		10160	06921
Ensembl ID		ENSG00000014138	ENSG00000173465
Uniprot IDs		Q14181	G3V1B8 O60232
PDB IDs		2KEB 4E2I 4Y97 5EXR	6HCZ
Enriched GO Terms of Interacting Partners?
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