MAPK8IP2 and SYNE2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	SYNE2
Description		mitogen-activated protein kinase 8 interacting protein 2	spectrin repeat containing nuclear envelope protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein-containing Complex Binding	Actin Binding Protein Binding Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Signaling Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway	Nuclear Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization
Pathways			Meiotic synapsis
Drugs
Diseases
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 28416818 30061737 29892015 22544366) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		85 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	14 interacting genes: ABI1 ACTC1 BRAP CALM1 ESR2 GLE1 MAPK3 MAPK8IP2 MEOX2 MTNR1B NR2C1 PML SASH1 UBC
Entrez ID		23542	23224
HPRD ID		09674	09763
Ensembl ID		ENSG00000008735	ENSG00000054654
Uniprot IDs		Q13387	Q6MZP0 Q8WXH0
PDB IDs			4DXS 4FI9 6XF1
Enriched GO Terms of Interacting Partners?
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