SYNE2 and NR2C1

		SYNE2	NR2C1
Description		spectrin repeat containing nuclear envelope protein 2	nuclear receptor subfamily 2 group C member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome	Chromatin Nucleoplasm PML Body
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Signaling Receptor Activity Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development
Pathways		Meiotic synapsis	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 28416818 30061737 29892015 22544366) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)	Body fat mass ( 28552196) Chromosomal aberration frequency (chromosome type) ( 31586183) Coronary artery disease ( 32469254) Intracranial aneurysm ( 33199917) Trunk fat mass ( 28552196)
Interacting Genes		14 interacting genes: ABI1 ACTC1 BRAP CALM1 ESR2 GLE1 MAPK3 MAPK8IP2 MEOX2 MTNR1B NR2C1 PML SASH1 UBC	9 interacting genes: AR ESR1 HDAC3 HDAC4 NR2C2 NRIP1 NUDT3 RARA SYNE2
Entrez ID		23224	7181
HPRD ID		09763	03318
Ensembl ID		ENSG00000054654	ENSG00000120798
Uniprot IDs		Q6MZP0 Q8WXH0	H9NIM2 H9NIM3 P13056
PDB IDs		4DXS 4FI9 6XF1
Enriched GO Terms of Interacting Partners?
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