EZH2 and MELK

  • Number of citations of the paper that reports this interaction (PubMedID 31434700)
  • 8
  • Data Source:
  • BioGRID (enzymatic study)

EZH2

MELK

Description enhancer of zeste 2 polycomb repressive complex 2 subunit maternal embryonic leucine zipper kinase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronotype ( 30696823)
  • Colorectal or endometrial cancer ( 26621817)
  • Crohn's disease ( 28067908)
  • Familial squamous cell lung carcinoma ( 29924316)
  • Height ( 25282103 31562340)
  • Inflammatory bowel disease ( 28067908)
  • Mean reticulocyte volume ( 32888494)
  • Mean spheric corpuscular volume ( 32888494)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes 77 interacting genes: AKT1 AR ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK2 CDK6 CDKN2B-AS1 CEP63 CRY2 DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H3-4 HDAC1 HOTAIR JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 LINC00511 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 MYCN NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 USP1 VAV1 WDR61 WSB2 ZMYND11 11 interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622
Entrez ID 2146 9833
HPRD ID 03342 06119
Ensembl ID ENSG00000106462 ENSG00000165304
Uniprot IDs A0A090N8E9 Q15910 S4S3R8 B7Z1G6 Q14680
PDB IDs 2C6V 4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6P5L 6U4Y 6WKR 7AT8 4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC 5K00 5M5A 5MAF 5MAG 5MAH 5MAI 5TVT 5TWL 5TWU 5TWY 5TWZ 5TX3 6GVX 6VXR
Enriched GO Terms of Interacting Partners?
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