DTX1 and UBE2C

Number of citations of the paper that reports this interaction (PubMedID 19690564)
64

Data Source:
BioGRID (two hybrid)

		DTX1	UBE2C
Description		deltex E3 ubiquitin ligase 1	ubiquitin conjugating enzyme E2 C
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Nuclear Body	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Transcription, DNA-templated Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cellular Response To Leukemia Inhibitory Factor	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Exit From Mitosis Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Coffee consumption ( 29367735) Retinitis pigmentosa ( 33514863) Visceral adipose tissue adjusted for BMI ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Height ( 31562340)
Interacting Genes		21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U	25 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RELA RNF31 TNNC1 TRIM21 TRIM28 TRIM29 UBA1 UBASH3B UBE3D
Entrez ID		1840	11065
HPRD ID		03991	05717
Ensembl ID		ENSG00000135144	ENSG00000175063
Uniprot IDs		Q86Y01	A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3
PDB IDs		6Y5N 6Y5P	1I7K 4YII 5A31 5KHR 5L9U
Enriched GO Terms of Interacting Partners?
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