DTX1 and DEFA5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DTX1	DEFA5
Description		deltex E3 ubiquitin ligase 1	defensin alpha 5
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Nuclear Body	Extracellular Region Extracellular Space Golgi Lumen Transport Vesicle Midbody Secretory Granule Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cellular Response To Leukemia Inhibitory Factor	Innate Immune Response In Mucosa Antibacterial Humoral Response Killing Of Cells Of Other Organism Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Membrane Disruption In Other Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Positive Regulation Of Membrane Permeability
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Defensins Alpha-defensins
Drugs
Diseases
GWAS		Body mass index ( 26426971) Coffee consumption ( 29367735) Retinitis pigmentosa ( 33514863) Visceral adipose tissue adjusted for BMI ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Basophil count ( 32888494) Blood protein levels ( 30072576) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Mercury levels ( 26025379)
Interacting Genes		21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U	4 interacting genes: ACE2 DTX1 MEOX2 PRSS1
Entrez ID		1840	1670
HPRD ID		03991	02720
Ensembl ID		ENSG00000135144	ENSG00000164816
Uniprot IDs		Q86Y01	Q01523
PDB IDs		6Y5N 6Y5P	1ZMP 2LXZ 2MIT 3I5W 4E82 4E83 4E86 4RBW 4RBX 5CUI 5CUJ 5CUM
Enriched GO Terms of Interacting Partners?
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