UBE2C and UBE3D

Number of citations of the paper that reports this interaction (PubMedID 15749827)
6

Data Source:
BioGRID (pull down)

		UBE2C	UBE3D
Description		ubiquitin conjugating enzyme E2 C	ubiquitin protein ligase E3D
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane	Ubiquitin Ligase Complex Nucleus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Cyclin Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Exit From Mitosis Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Protein Polyubiquitination Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 31562340)	Adult body size ( 32376654) Crohn's disease ( 26891255) Entorhinal cortical volume ( 31530798) Heel bone mineral density ( 30598549 28869591) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189)
Interacting Genes		25 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RELA RNF31 TNNC1 TRIM21 TRIM28 TRIM29 UBA1 UBASH3B UBE3D	3 interacting genes: CCNB1 MAGEA11 UBE2C
Entrez ID		11065	90025
HPRD ID		05717	12861
Ensembl ID		ENSG00000175063	ENSG00000118420
Uniprot IDs		A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3	Q4G0J6 Q4G0X5 Q7Z6J8
PDB IDs		1I7K 4YII 5A31 5KHR 5L9U
Enriched GO Terms of Interacting Partners?
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