DRD2 and TRPC4

  • Number of citations of the paper that reports this interaction (PubMedID 18261457)
  • 12

DRD2

TRPC4

Description dopamine receptor D2 transient receptor potential cation channel subfamily C member 4
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alcohol consumption ( 31358974)
  • Alcohol consumption (drinks per week) ( 30643258 30679032)
  • Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841)
  • Alcohol use disorder ( 30940813)
  • Alcohol use disorder (consumption score) ( 33861876)
  • Alcoholic chronic pancreatitis ( 28754779)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Anxiety ( 33859377)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Bipolar disorder ( 33263727)
  • Body mass index ( 26426971)
  • Chronotype ( 30696823)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Depression ( 33859377)
  • General factor of neuroticism ( 30867560)
  • Inferior temporal gyrus volume ( 31530798)
  • Information processing speed ( 25869804)
  • Interferon alpha levels in systemic lupus erythematosus ( 25338677)
  • Mood instability ( 31168069)
  • Neuroticism ( 27089181 29255261)
  • Problematic alcohol use ( 32451486)
  • Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
  • Schizophrenia ( 28991256 25056061 29483656 30285260)
  • Select biomarker traits ( 17903293)
  • Sleep duration ( 27992416)
  • Smoking cessation ( 33082346)
  • Smoking status (current vs mixed) ( 33082346)
  • Smoking status (current vs never) ( 33082346)
  • Sociability score ( 34054130)
  • Systolic blood pressure in sickle cell anemia ( 24058526)
  • Triglycerides ( 30275531)
  • Walking pace ( 33128006)
  • Worry too long after an embarrassing experience ( 34054130)
  • Age-related macular degeneration ( 23326517)
  • Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
  • Mild influenza (H1N1) infection ( 26379185)
  • Obesity-related traits ( 23251661)
  • Smoking initiation ( 30617275 33082346)
  • Smoking initiation (ever regular vs never regular) ( 30679032)
  • Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes 99 interacting genes: ABCA2 ADGRB1 ADGRG1 ADORA2A APH1A ARL1 ARL6IP6 ATP6V0A2 ATP6V0C BCAP29 BCAP31 CADPS CADPS2 CALM1 CALM3 CASP1 CCKBR CCNA2 CD3E CD3G CERS1 CERS2 CHPT1 CLDND1 CLIC6 CRELD1 E2F6 EPB41 EPB41L1 FLNA GABBR1 GABBR2 GDPD2 GHITM GIPC1 GNAI2 GNAI3 GNAZ GNB5 GPC6 GPR137 GPR37 GRIA2 GRINA HRH3 IL10RA INPPL1 KBTBD6 KBTBD7 KCNJ6 KCNJ9 LPAR1 NCS1 NDUFV1 NEFM NQO2 NSF OPRM1 PAQR6 PAWR PIGG PLLP PLPPR3 PPP1R9B PSG7 RBM22 RHBDD2 RTN1 RTN3 RTN4 SERINC3 SGSH SLC15A4 SLC22A17 SLC35B1 SLC4A3 SLC6A1 SLC6A3 SMIM7 SPP1 SSTR2 SSTR5 SYNGR2 TF TMEFF2 TMEM101 TMEM11 TMEM63A TRAM1 TRPC4 TRPC5 TSPAN3 TSPAN7 TTYH1 VWA5A WFS1 WLS YIPF3 ZDHHC4 10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5
Entrez ID 1813 7223
HPRD ID 00539 09154
Ensembl ID ENSG00000149295 ENSG00000133107
Uniprot IDs A0A024R3C5 A0A024R3I6 P14416 Q9UBN4
PDB IDs 1I15 5AER 6CM4 6LUQ 6VMS 7JVR
Enriched GO Terms of Interacting Partners?
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