ACE and COMT

  • Number of citations of the paper that reports this interaction (PubMedID 12729939)
  • 6
  • Data Source:
  • HPRD (in vivo)

ACE

COMT

Description angiotensin I converting enzyme catechol-O-methyltransferase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adventurousness ( 30643258)
  • Alzheimer's disease (late onset) ( 24162737 30820047)
  • Alzheimer's disease or family history of Alzheimer's disease ( 33589840)
  • Angiotensin-converting enzyme activity ( 20066004)
  • Blood metabolite levels ( 24816252)
  • Blood metabolite ratios ( 24816252)
  • Blood protein levels ( 30072576)
  • Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798)
  • Diastolic blood pressure ( 28135244 27841878 28739976)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Hodgkin's lymphoma ( 34216518)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Medication use (calcium channel blockers) ( 31015401)
  • Metabolic traits ( 21886157)
  • Metabolite levels ( 23281178)
  • Serum metabolite levels ( 33031748 24625756 23093944)
  • Systolic blood pressure ( 27841878 30578418)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Type 2 diabetes ( 30297969)
  • Blood metabolite levels ( 24816252)
  • Serum metabolite levels ( 23093944)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Urinary metabolite levels in chronic kidney disease ( 31959995)
  • Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes 5 interacting genes: AGTR2 BDKRB2 COMT CSNK2A1 DCAF7 74 interacting genes: ACE AQP7 AVPR2 BEST2 BRS3 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 FXR2 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HCK HIBADH HOPX HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MFSD14B MRPS5 MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC7A1 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2 ZNF43
Entrez ID 1636 1312
HPRD ID 00108 00284
Ensembl ID ENSG00000159640 ENSG00000093010
Uniprot IDs B4DKH4 P12821 A0A140VJG8 P21964
PDB IDs 1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK 4BZR 4BZS 4C2N 4C2O 4C2P 4C2Q 4C2R 4CA5 4CA6 4UFA 4UFB 5AM8 5AM9 5AMA 5AMB 5AMC 6EN5 6EN6 6F9R 6F9T 6F9U 6F9V 6H5W 6H5X 6QS1 6TT1 6TT3 6TT4 6ZPQ 6ZPT 6ZPU 3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D
Enriched GO Terms of Interacting Partners?
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