COMT and REEP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		COMT	REEP4
Description		catechol-O-methyltransferase	receptor accessory protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendrite Dendritic Spine Intracellular Membrane-bounded Organelle Cell Body Postsynaptic Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Integral Component Of Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity L-dopa O-methyltransferase Activity Orcinol O-methyltransferase Activity	Protein Binding Microtubule Binding
	Biological Process	Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Xenobiotic Stimulus Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Response To Estrogen Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain	Nuclear Envelope Organization Mitotic Nuclear Membrane Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization
Pathways		Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS	Olfactory Signaling Pathway
Drugs		Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone
Diseases
GWAS		Blood metabolite levels ( 24816252) Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Frailty index ( 34431594) Hypertriglyceridemia ( 23505323)
Interacting Genes		74 interacting genes: ACE AQP7 AVPR2 BEST2 BRS3 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 FXR2 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HCK HIBADH HOPX HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MFSD14B MRPS5 MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC7A1 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2 ZNF43	97 interacting genes: AGPAT4 BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L C4orf3 CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM167B TMEM18 TMEM19 TMEM199 TMEM208 TMEM229B TMEM254 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VTI1B YIF1A YIPF4
Entrez ID		1312	80346
HPRD ID		00284	09864
Ensembl ID		ENSG00000093010	ENSG00000168476
Uniprot IDs		A0A140VJG8 P21964	E5RGS2 Q9H6H4
PDB IDs		3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D
Enriched GO Terms of Interacting Partners?
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