CLEC14A and PMP22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLEC14A	PMP22
Description		C-type lectin domain containing 14A	peripheral myelin protein 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Compact Myelin Synapse
	Molecular Function	Protein Binding Carbohydrate Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Protein Binding
	Biological Process	Lymphangiogenesis Cell Migration Involved In Sprouting Angiogenesis Cell Migration Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Receptor-3 Signaling Pathway	Chemical Synaptic Transmission Peripheral Nervous System Development Cell Death Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Resveratrol
Diseases
GWAS		Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Two-hour glucose ( 34059833) Type 2 diabetes ( 30297969 32499647) Type 2 diabetes (age of onset) ( 28060188)	Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)
Interacting Genes		13 interacting genes: ATP6V0C CLDN19 CLDN4 CYB561D2 EMD LHFPL5 MALL MGST2 MS4A1 PMP22 TMEM243 TSPAN2 VAMP3	59 interacting genes: APOL3 ARL13B ASGR2 ATP6AP2 C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SCN3B SDC4 SHISAL1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12
Entrez ID		161198	5376
HPRD ID		10711	03059
Ensembl ID		ENSG00000176435	ENSG00000109099
Uniprot IDs		Q86T13	A8MU75 Q01453 Q6FH25
PDB IDs
Enriched GO Terms of Interacting Partners?
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