CLEC14A and ATP6V0C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLEC14A	ATP6V0C
Description		C-type lectin domain containing 14A	ATPase H+ transporting V0 subunit c
Image		No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Lymphangiogenesis Cell Migration Involved In Sprouting Angiogenesis Cell Migration Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Receptor-3 Signaling Pathway	ATP Synthesis Coupled Proton Transport Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Resveratrol	Tiludronic acid
Diseases
GWAS		Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Two-hour glucose ( 34059833) Type 2 diabetes ( 30297969 32499647) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		13 interacting genes: ATP6V0C CLDN19 CLDN4 CYB561D2 EMD LHFPL5 MALL MGST2 MS4A1 PMP22 TMEM243 TSPAN2 VAMP3	53 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12
Entrez ID		161198	527
HPRD ID		10711	00162
Ensembl ID		ENSG00000176435	ENSG00000185883
Uniprot IDs		Q86T13	P27449
PDB IDs			6WLW 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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