CYP3A4 and CYP2C9

  • Number of citations of the paper that reports this interaction (PubMedID 20215413)
  • 27

CYP3A4

CYP2C9

Description cytochrome P450 family 3 subfamily A member 4 cytochrome P450 family 2 subfamily C member 9
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Metabolic traits ( 21886157)
  • Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952)
  • Pre-treatment viral load in HIV-1 infection ( 31219150)
  • Sex hormone levels ( 26014426)
  • Tacrolimus trough concentration in kidney transplant patients ( 29160300)
  • Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)
  • Blood metabolite levels ( 24816252)
  • Clopidogrel active metabolite levels ( 28207573)
  • Dehydroepiandrosterone sulphate levels ( 21533175)
  • Diastolic blood pressure ( 27841878)
  • glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292)
  • Immune response to smallpox vaccine (IL-6) ( 22542470)
  • Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102)
  • Pulse pressure ( 27841878)
  • Response to clopidogrel therapy ( 28207573 19706858)
  • Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
  • Serum metabolite levels ( 23093944)
  • Systolic blood pressure ( 27841878)
  • Warfarin maintenance dose ( 18535201 23755828 20833655 19300499 26265036)
Interacting Genes 8 interacting genes: CYB5A CYP2C9 GK POR PRKACA PRKCA STUB1 UGT2B7 10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A
Entrez ID 1576 1559
HPRD ID 00484 03084
Ensembl ID ENSG00000160868 ENSG00000138109
Uniprot IDs P08684 Q6GRK0 P11712 S5RV20
PDB IDs 1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R 5G5J 5TE8 5VC0 5VCC 5VCD 5VCE 5VCG 6BCZ 6BD5 6BD6 6BD7 6BD8 6BDH 6BDI 6BDK 6BDM 6OO9 6OOA 6OOB 7KVH 7KVI 7KVJ 7KVK 7KVM 7KVN 7KVO 7KVP 7KVQ 7KVS 1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI 6VLT
Enriched GO Terms of Interacting Partners?
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