KLHL2 and TNPO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		KLHL2	TNPO2
Description		kelch like family member 2	transportin 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Nucleus Cytoplasm
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Protein Ubiquitination	Protein Import Into Nucleus
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		32 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA FRAS1 KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	53 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C12orf40 C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RAN RBM45 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 TRMT1 ZBTB32 ZC2HC1C
Entrez ID		11275	30000
HPRD ID		09311	04301
Ensembl ID		ENSG00000109466	ENSG00000105576
Uniprot IDs		B4DFZ5 E9PEX9 O95198	A0A024R7F7 O14787 Q05D48 Q4LE60
PDB IDs		2XN4 4CHB
Enriched GO Terms of Interacting Partners?
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