KLHL2 and KLHL3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		KLHL2	KLHL3
Description		kelch like family member 2	kelch like family member 3
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding
	Biological Process	Protein Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		32 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA FRAS1 KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	18 interacting genes: ACSL6 AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 KLHL2 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 TNPO2 WNK3 WNK4
Entrez ID		11275	26249
HPRD ID		09311	09011
Ensembl ID		ENSG00000109466	ENSG00000146021
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q9UH77
PDB IDs		2XN4 4CHB	4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?
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