PTPN21 and PAK5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PTPN21	PAK5
Description		protein tyrosine phosphatase non-receptor type 21	p21 (RAC1) activated kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Synapse
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		28 interacting genes: AKAP1 BAG3 BMX CATSPER1 CWC22 ERBB4 FAM214B FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 TTC8 UBASH3B VPS26C YAP1 ZNF497	34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT
Entrez ID		11099	57144
HPRD ID		04468	06423
Ensembl ID		ENSG00000070778	ENSG00000101349
Uniprot IDs		Q16825	B0AZM9 Q9P286
PDB IDs			2F57
Enriched GO Terms of Interacting Partners?
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