PAK5 and RHOJ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PAK5	RHOJ
Description		p21 (RAC1) activated kinase 5	ras homolog family member J
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Synapse	Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	GTPase Activity Protein Binding GTP Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Angiogenesis Endocytosis Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Cdc42 Protein Signal Transduction Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle	RHOJ GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)
Interacting Genes		34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT	25 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 CDC42EP1 DOCK10 DOCK8 GOLGA2 MEOX2 PAK1 PAK2 PAK3 PAK5 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS WASL ZNF426
Entrez ID		57144	57381
HPRD ID		06423	09632
Ensembl ID		ENSG00000101349	ENSG00000126785
Uniprot IDs		B0AZM9 Q9P286	A0A024R692 Q7Z513 Q9H4E5
PDB IDs		2F57
Enriched GO Terms of Interacting Partners?
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