CLP1 and FGF16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLP1	FGF16
Description		cleavage factor polyribonucleotide kinase subunit 1	fibroblast growth factor 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Protein Binding ATP Binding Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity Polydeoxyribonucleotide Kinase Activity Polyribonucleotide 5'-hydroxyl-kinase Activity	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	MRNA Polyadenylation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing Phosphorylation Cerebellar Cortex Development Targeting Of MRNA For Destruction Involved In RNA Interference MRNA 3'-end Processing SiRNA Loading Onto RISC Involved In RNA Interference	Positive Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Temperature Stimulus Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Migration Regulation Of MAP Kinase Activity Positive Regulation Of Brown Fat Cell Proliferation Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)	Height ( 31562340)
Interacting Genes		17 interacting genes: APP CEP164 CPSF3 CREB3 DAGLB FGF16 FTO HCFC1 MEOX2 MESD NUDT21 PCMT1 PRR3 PSMB5 SNF8 TSEN54 YJU2B	10 interacting genes: APP CLP1 DVL3 HOOK2 INCA1 KRT31 MCC MFHAS1 PICK1 PTX3
Entrez ID		10978	8823
HPRD ID		16382	04764
Ensembl ID		ENSG00000172409	ENSG00000196468
Uniprot IDs		Q92989	O43320
PDB IDs
Enriched GO Terms of Interacting Partners?
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