CLP1 and SNF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLP1	SNF8
Description		cleavage factor polyribonucleotide kinase subunit 1	SNF8 subunit of ESCRT-II
Image		No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity Polydeoxyribonucleotide Kinase Activity Polyribonucleotide 5'-hydroxyl-kinase Activity	Protein Binding Protein C-terminus Binding Channel Regulator Activity Protein Homodimerization Activity Protein N-terminus Binding
	Biological Process	MRNA Polyadenylation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing Phosphorylation Cerebellar Cortex Development Targeting Of MRNA For Destruction Involved In RNA Interference MRNA 3'-end Processing SiRNA Loading Onto RISC Involved In RNA Interference	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Regulation Of Viral Budding Via Host ESCRT Complex
Pathways		tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)	Coronary heart disease ( 21378990) Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 29358691)
Interacting Genes		17 interacting genes: APP CEP164 CPSF3 CREB3 DAGLB FGF16 FTO HCFC1 MEOX2 MESD NUDT21 PCMT1 PRR3 PSMB5 SNF8 TSEN54 YJU2B	25 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 HMOX1 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA VAC14 VPS25 VPS36 YWHAE
Entrez ID		10978	11267
HPRD ID		16382	16847
Ensembl ID		ENSG00000172409	ENSG00000159210
Uniprot IDs		Q92989	Q96H20
PDB IDs			2ZME 3CUQ
Enriched GO Terms of Interacting Partners?
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