GNA13 and ARHGEF1

Number of citations of the paper that reports this interaction (PubMedID 9641916)
201

Data Source:
HPRD (in vivo)

		GNA13	ARHGEF1
Description		G protein subunit alpha 13	Rho guanine nucleotide exchange factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Activation Of Phospholipase D Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)	Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)
Interacting Genes		31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	11 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4
Entrez ID		10672	9138
HPRD ID		05100	03511
Ensembl ID		ENSG00000120063	ENSG00000076928
Uniprot IDs		A0A024R8M0 Q14344	A0A024R0R1 Q92888
PDB IDs			1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A
Enriched GO Terms of Interacting Partners?
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