NANOG and USP21

Number of citations of the paper that reports this interaction (PubMedID 30809310)
6

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology)

		NANOG	USP21
Description		Nanog homeobox	ubiquitin specific peptidase 21
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding
	Biological Process	Endodermal Cell Fate Specification Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Stem Cell Proliferation	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: BRAF MED12 PRKCE RBPMS RHOXF2 SPOP USP21	54 interacting genes: ATXN3 AURKA BAP1 BRCA2 CBL CBLC DTX3 ESPL1 EXOSC10 FOXM1 H2AC18 ISG15 JOSD1 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		79923	27005
HPRD ID		06397	05291
Ensembl ID		ENSG00000111704	ENSG00000143258
Uniprot IDs		A8K4D1 Q9H9S0	Q9UK80
PDB IDs		2KT0 4RBO	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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