MED8 and MED25

Number of citations of the paper that reports this interaction (PubMedID 14638676)
11

Data Source:
HPRD (in vivo)

		MED8	MED25
Description		mediator complex subunit 8	mediator complex subunit 25
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mediator Complex Core Mediator Complex	Nucleoplasm Mediator Complex Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Feeling worry ( 29500382) Schizophrenia ( 28991256)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		31 interacting genes: APP ARRB2 CCNC CDK8 CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 THOC7 UBALD1 USP49	14 interacting genes: CDK8 CREBBP CTDP1 HCFC1 MED1 MED15 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA
Entrez ID		112950	81857
HPRD ID		06991	14380
Ensembl ID		ENSG00000159479	ENSG00000104973
Uniprot IDs		Q96G25	M0QZQ2 Q71SY5
PDB IDs			2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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