TRAF4 and HGS

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		TRAF4	HGS
Description		TNF receptor associated factor 4	hepatocyte growth factor-regulated tyrosine kinase substrate
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Bicellular Tight Junction Perinuclear Region Of Cytoplasm Plasma Membrane Receptor Complex	Lysosome Endosome Early Endosome Cytosol Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding WW Domain Binding	Protein Binding Protein Domain Specific Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding
	Biological Process	Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Respiratory Tube Development Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein K63-linked Ubiquitination	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Protein Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of MAP Kinase Activity Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways			EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion
Drugs			Citric Acid
Diseases
GWAS			Eye color traits ( 20463881)
Interacting Genes		78 interacting genes: ALKBH4 BAHD1 BANP BCKDK BCL6B BEX3 BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FAM214B FAM90A1 FAT1 FBXL18 FTH1 GOLGA2 GORASP2 GPRASP1 HGS HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NOS1AP NPAS2 NTRK1 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS1 RBPMS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2D1 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581 ZNF688	182 interacting genes: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG C1orf94 CASK CBS CCDC103 CCDC114 CCDC136 CCDC33 CDR2 CEP55 CEP57L1 CEP63 CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAJC5 DYDC1 EGFR EHMT2 EPS15 ESRRG EXOC5 EXOC7 EXOC8 FAM168A FANCG FCHSD2 FLOT1 FLOT2 GFAP GFI1B GGA2 GKAP1 GOLGA2 HAP1 HNRNPDL HSFY1 HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KIAA0753 KRT13 KRT15 KRT18 KRT19 KRT31 KRT33B KRT38 KRT40 KRT6A KRTAP26-1 LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD8 NEFL NF2 NMI NPAS2 NUP54 NUP62 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 PMEPA1 PNMA1 POGZ PPP1R16A PPP1R7 PTCD3 RBCK1 RFX6 RHOBTB3 RINT1 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 SS18L1 STAM STAM2 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TEKT1 TFG TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TRAF4 TRAK1 TRAP1 TRIM17 TRIM27 TRIM69 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 ZNF302
Entrez ID		9618	9146
HPRD ID		03915	05085
Ensembl ID		ENSG00000076604	ENSG00000185359
Uniprot IDs		A0A024QZ19 A0A024QZ59 Q9BUZ4	A0A0S2Z4R4 O14964
PDB IDs		2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1	2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?
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